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Tumor Microenvironment Cellular and molecular basis of inflammation and fibrosis Key words: inflammation, fibrosis, extracellular matrix, mouse genetics, ageing, dynamic macromolecular complexes, cell polarity, alternative splicing This laboratory is studying the cellular and molecular basis of inflammation and fibrosis, with a particular focus on the role of stromal cells and extracellular matrix ECM , in the context of chronic inflammatory diseases and cancer. The molecular pathways currently being studied include the adhesion receptor CD44 and its principle ligand, hyaluronan, and fibroblast activation protein FAP , a stromal cell surface protease. Studies of CD44 and FAP are being conducted in mouse models of cancer, cardiovascular disease and pulmonary fibrosis using conditional CD44 knockout mice and FAP-null mice generated in the lab. Also the FAP promoter has been exploited to generate mice that can be used to non-invasively image reactive stromal cells in fibrotic lesions and epithelial-derived tumors, to conditionally ablate reactive stromal cells, and to manipulate gene expression specifically in fibrotic lesions and tumor stromal cells. We are studying the impact of matrix modification on cell behavior directly through regulation of receptor mediated signal transduction as well as through modulation of tissue stiffness. Lung cellular and molecular physiology : ,
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This was a big job, but an interesting one! They're huge, charismatic, and the very possibility of their presence makes for an exciting dive. You'd be forgiven, then, for thinking that scientists are equally familiar with their lives.

Your comments (7)

  1. Kazralrajas
    Kazralrajas 2 months ago

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  2. Gamuro 2 months ago

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  3. Mezahn 2 months ago

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  5. Zujind 2 months ago

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  6. Vudora 2 months ago

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