Tumor Microenvironment Cellular and molecular basis of inflammation and fibrosis Key words: inflammation, fibrosis, extracellular matrix, mouse genetics, ageing, dynamic macromolecular complexes, cell polarity, alternative splicing This laboratory is studying the cellular and molecular basis of inflammation and fibrosis, with a particular focus on the role of stromal cells and extracellular matrix ECM , in the context of chronic inflammatory diseases and cancer. The molecular pathways currently being studied include the adhesion receptor CD44 and its principle ligand, hyaluronan, and fibroblast activation protein FAP , a stromal cell surface protease. Studies of CD44 and FAP are being conducted in mouse models of cancer, cardiovascular disease and pulmonary fibrosis using conditional CD44 knockout mice and FAP-null mice generated in the lab. Also the FAP promoter has been exploited to generate mice that can be used to non-invasively image reactive stromal cells in fibrotic lesions and epithelial-derived tumors, to conditionally ablate reactive stromal cells, and to manipulate gene expression specifically in fibrotic lesions and tumor stromal cells. We are studying the impact of matrix modification on cell behavior directly through regulation of receptor mediated signal transduction as well as through modulation of tissue stiffness. Lung cellular and molecular physiology : ,
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Your comments (7)
Kazralrajas 2 months ago
russian girls are so damn hot lmfao
Gamuro 2 months ago
awesome scene I shot hot gum all over my face and body on this one
Mezahn 2 months ago
That silhouette part of the scene at lik 23:00 was great
Brazil 2 months ago
love love love it!
Zujind 2 months ago
Haha damn she said NOPE at 32:20
Vudora 2 months ago
It's at times like this I wish I had a stepsister.